The hepatotoxic action of carbon tetrachloride stimulatory effect of carbon tetrachloride on lipid peroxidation in microsomal suspensions
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چکیده
منابع مشابه
Antagonism by chloramphenicol of carbon tetrachloride hepatotoxicity. Examination of microsomal cytochrome P-450 and lipid peroxidation.
Administration of chloramphenicol early in Ccl, intoxication prevents lipid peroxidation of endoplasmic reticulum membranes. Conversely, a sulfamoyl analog, Tevenel, was ineffective in preventing the lipoperoxidative process. Likewise, in an in vitro microsomal system chloramphenicol inhibited a lipid peroxidation process and Tevenel did not. However, both compounds bind to cytochrome P-450. Ch...
متن کاملLipid metabolites of carbon tetrachloride.
5 min after intravenous injection into rats of (14)C- or (36)Cl-carbon tetrachloride, liver lipids were found labeled. Most of the radioactivity was found in the phospholipid fraction. The metabolites were shown to comprise a heterogeneous group of branched long-chain chlorinated fatty acids, probably containing the trichloromethyl side chain. Surviving liver slices also formed these metabolite...
متن کاملLipid peroxidation inactivates rat liver microsomal glycerol-3-phosphate acyl transferase. Effect of iron and copper salts and carbon tetrachloride.
Lipid peroxidation is known to affect the activity of several enzymes including microsomal enzymes such as glucose-6-phosphatase; but its effect on the enzymes of lipid biosynthesis has not been investigated. Glycerol-3-phosphate acyltransferase (GPAT) represents the first committed step and probably the rate limiting step in glycerolipid synthesis and thus may be a good candidate for study. Ra...
متن کاملCarbon Tetrachloride in Helminthiasis
In the Journal of the American Mcdical Association of November 19th, 1921, there appeared a note by Maurice C. Hall on the use of Carbon tetrachloride for the removal of hookworms in animals. Dr. Hall is the senior zoologist, United States Bureau of Animal Industry, and he found this drug to be a powerful anthelmintic in dogs* and suggested its trial in human uncinariasis. Carbon tetrachloride ...
متن کاملSeparation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions.
Carbonyl products were separated and identified in suspensions of rat liver microsomal fractions and in isolated hepatocytes, after stimulation of lipid peroxidation by incubation with the pro-oxidants CCl4 and ADP-iron. The carbonyl products were allowed to react with 2,4-dinitrophenylhydrazine, and the derivatives were extracted and separated by t.l.c. into three zones of non-polar materials,...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1970
ISSN: 0014-5793
DOI: 10.1016/0014-5793(70)80510-5